wireless eeg telemetry devices hd-x02  (Data Sciences International)

Journal: Brain research

Article Title: Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease

doi: 10.1016/j.brainres.2014.07.029

Figure Lengend Snippet: Chronic cortical EEG and synchronous video recording performed in WT, GFAP KO, and AxD mice after TBI. n = 4 mice per group. (A) The non-epileptiform discharges in mice were consistent in both left (LC) and right cortex (RC). (B) Example of baseline non-convulsive events at four months of age. Tg73.7 and R236H mice showed more frequent spontaneous discharge, while GFAP KO and WT remained relatively silent. EEG traces were calibrated to 10 seconds and 1mV. (C) Higher magnification of EEG traces demonstrates higher frequency of non-convulsive discharges in TG73.7 and R236H mice when compared to WT and GFAP KO mice. EEG traces were calibrated to 1 second and 0.5 mV. (D) Tg73.7 mice exhibited significantly more non-convulsive events per hour (P < 0.05, 2-way ANOVA) and higher spike discharge frequency (P < 0.05, 2-way ANOVA) when compared to WT and GFAP KO mice. Whereas event frequency followed a trend to decrease in an age-dependent manner (P >0.05, 2-way ANOVA), the frequency of the non-convulsive events peaked at four months of age. R236H exhibited significantly higher spike discharge frequency (P< 0.05, 2-way ANOVA), but did not exhibit significantly more non-convulsive events per hour (P> 0.05, 2-way ANOVA).

Article Snippet: 3 months after the TBI, mice were fitted with wireless telemetry EEG devices (Data Science International) allowing free movements.

Techniques: